Causes and symptoms
The exact causes of breast cancer are largely unknown, but both environmental and genetic factors are involved. Specific mutations in genes called HER2, CHEK2, and p53 have been linked to breast cancer; these mutations may be inherited or acquired.Mutations that are inherited often substantially increase a person’s risk for developing breast cancer. For example, whereas some 12 percent of women in the general population develop breast cancer, roughly 60 percent of women who inherit mutations in BRCA1 or BRCA2 eventually develop the disease. Women who carry these mutations also have an increased risk of. About 9 percent of men carrying BRCA1 or BRCA2 mutations will develop breast cancer by age 80.
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